Think about the conclusion you’re driving your audience toward, or what you’re trying to convince them. If you can’t come up with a model in your head about how your discoveries have changed your thinking about a process, pathway or technical approach, then it will be very difficult to write a full paper. The last figure is also often a schematic or model, which is referred to in the discussion. Build your final model and make it clear. I like to put a schematic at the beginning demonstrating the overall concept and what’s unique about the approach.Find a balance of main body data and supplemental information. Some journals may have limitations on the main body figures, but typically you should be able to have four or five main body figures without crowding the text.This kind of story, from the beginning to the end with an impactful finish, helps you put together an outline that you can use to write. If I’m studying a new drug compound, for example, I’ll introduce it at the beginning, add the supporting data on the mechanisms and how it works, and end with data showing its effectiveness in different cell lines. Finally, you want to save your most relevant data for the last figure. Then, add the support of that breakthrough through the next figures. You want to put your most compelling figures first, to get the attention of the reader and set them up for your big breakthrough.
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